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Alternative name
GRB14, GRB14 adapter protein antibody
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Catalog
A003641
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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Immunogengrowth factor receptor-bound protein 14
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IHCImmunohistochemistry of paraffin-embedded human ovary tumor using A003641(GRB14 antibody) at dilution of 1:50
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Western BlotDU 145 cells were subjected to SDS PAGE followed by western blot with A003641( GRB14 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalAdapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
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Gene nameGRB14
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Uniprot IDQ14449
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Observed M.W.61kd
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