anti-AMFR antibody

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  • Alternative name

    AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45 antibody

  • Catalog
    A000358
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF,IP
  • PurificationImmunogen affinity purified
  • Immunogenautocrine motility factor receptor
  • IHCImmunohistochemistry of paraffin-embedded human ovary using A000358(AMFR antibody) at dilution of 1:100
  • Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A000358(AMFR antibody) at dilution of 1:800
  • Recommended dilutionWB :1:500-1:5000;IF:1:10-1:100;IHC:1:20-1:200;IP:1:200-1:2000
  • Product Description specificalE3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
  • Gene nameAMFR
  • locationEndoplasmic reticulum membrane
  • Uniprot IDQ9UKV5
  • Calculated M.W.73kDa
  • Observed M.W.73 kDa


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