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Alternative name
2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE antibody
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Catalog
A000355
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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Immunogenalpha-methylacyl-CoA racemase
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A000355(p50S,AMACR antibody) at dilution of 1:50
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Western BlotRecombinant AMACR protein were subjected to SDS PAGE followed by western blot with A000355( AMACR Antibody) at dilution of 1:1000
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200
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Product Description specificalAMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
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Gene nameAMACR
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locationMitochondrion,Peroxisome
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Uniprot IDQ9UHK6
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Calculated M.W.42kDa
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Observed M.W.42 kDa
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