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Alternative name
ABH7, ALKBH7, SPATA11, UNQ6002 antibody
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Catalog
A000315
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenalkB, alkylation repair homolog 7 (E. coli)
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IHCImmunohistochemistry of paraffin-embedded human testis tissue slide using A000315( ALKBH7 Antibody) at dilution of 1:50
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Western Blothuman testis tissue were subjected to SDS PAGE followed by western blot with A000315(ALKBH7 antibody) at dilution of 1:500
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Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200
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Product Description specificalMay function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
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Gene nameALKBH7
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locationMitochondrion
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Uniprot IDQ9BT30
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Calculated M.W.25kDa
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Observed M.W.25kd
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