-
Alternative name
FKBP36 antibody
-
Catalog
A003146
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC
-
PurificationImmunogen affinity purified
-
ImmunogenFK506 binding protein 6, 36kDa
-
IHCImmunohistochemistry of paraffin-embedded human testis using A003146(FKBP6 antibody) at dilution of 1:100
-
Western Blothuman testis tissue were subjected to SDS PAGE followed by western blot with A003146(FKBP6 antibody) at dilution of 1:600
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalCo-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
-
Gene nameFKBP6
-
Uniprot IDO75344
-
Observed M.W.36kd
-