StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogenfermitin family homolog 3 (Drosophila)
IHCImmunohistochemistry of paraffin-embedded human lymphoma using A003078(FERMT3 antibody) at dilution of 1:50
Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A003078(FERMT3 antibody) at dilution of 1:300
Recommended dilutionWB : 1:200-1:1000
Product Description specificalPlays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). _x000D_Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.