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Alternative name
FBG2, FBS2, FBX6 antibody
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Catalog
A003048
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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ImmunogenF-box protein 6
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IHCImmunohistochemistry of paraffin-embedded human gliomas using A003048(FBXO6 antibody) at dilution of 1:50
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Western Blotmouse liver tissue were subjected to SDS PAGE followed by western blot with A003048(FBXO6 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalSubstrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
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Gene nameFBXO6
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Uniprot IDQ9NRD1
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Observed M.W.35 kDa
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