-
Alternative name
FACD antibody
-
Catalog
A003006
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse
-
Applications Tested/SuitableELISA,WB,IHC,IP
-
PurificationImmunogen affinity purified
-
ImmunogenFanconi anemia, complementation group D2
-
IHCImmunohistochemistry of paraffin-embedded human testis using A003006(FANCD2 antibody) at dilution of 1:50
-
Western BlotHL-60 cells were subjected to SDS PAGE followed by western blot with A003006(FANCD2 antibody) at dilution of 1:300
-
Recommended dilutionWB : 1:200-1:1000
-
Product Description specificalRequired for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
-
Gene nameFANCD2
-
Uniprot IDQ9BXW9
-
Observed M.W.150-155kd
-