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Alternative name
ABRA1, CCDC98 antibody
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Catalog
A002974
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenfamily with sequence similarity 175, member A
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IHCImmunohistochemistry of paraffin-embedded human breast cancer using A002974(FAM175A antibody) at dilution of 1:100
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Western Blothuman testis tissue were subjected to SDS PAGE followed by western blot with A002974(FAM175A antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalInvolved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
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Gene nameFAM175A
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Uniprot IDQ6UWZ7
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Observed M.W.46 kDa
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