anti-EYA2 antibody

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  • Alternative name

    EAB1 antibody

  • Catalog
    A002914
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • Immunogeneyes absent homolog 2 (Drosophila)
  • IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A002914(EYA2 antibody) at dilution of 1:50
  • Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A002914(EYA2 antibody) at dilution of 1:100
  • Recommended dilutionWB : 1:200-1:1000
  • Product Description specificalFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).
  • Gene nameEYA2
  • Uniprot IDO00167
  • Observed M.W.57 kDa


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