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Alternative name
AKR1C4, HAKRA, CHDR, 3 alpha HSD1, Chlordecone reductase antibody
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Catalog
A000263
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF
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PurificationImmunogen affinity purified
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Immunogenaldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
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Western BlotMCF7 cells were subjected to SDS PAGE followed by western blot with A000263(AKR1C4 antibody) at dilution of 1:500
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Recommended dilutionWB :1:1000-1:10000;IF:1:10-1:100
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Product Description specificalCatalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
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Gene nameAKR1C4
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locationCytoplasm
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Uniprot IDP17516
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Calculated M.W.37kDa
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Observed M.W.37kd
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