anti-DYNLT1 antibody

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  • Alternative name

    TCTEL1, TCTEX-1, TCTEX1 antibody

  • Catalog
    A002590
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IP
  • PurificationImmunogen affinity purified
  • Immunogendynein, light chain, Tctex-type 1
  • IHCImmunohistochemistry of paraffin-embedded human pancreas using A002590(DYNLT1 antibody) at dilution of 1:50
  • Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A002590(DYNLT1 antibody) at dilution of 1:500
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalActs as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. _x000D_Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor- independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).
  • Gene nameDYNLT1
  • Uniprot IDP63172
  • Observed M.W.12 kDa




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