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Alternative name
AKAP10, D AKAP2, AKAP 10, PRKA10, D AKAP 2 antibody
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Catalog
A000250
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenA kinase (PRKA) anchor protein 10
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer using A000250(AKAP10 antibody) at dilution of 1:100
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A000250(AKAP10 antibody) at dilution of 1:500
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-200
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Product Description specificalDifferentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).
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Gene nameAKAP10
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locationCytoplasm,Membrane,Mitochondrion
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Uniprot IDO43572
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Calculated M.W.74kDa
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Observed M.W.74kd
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