StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
ImmunogenDnaJ (Hsp40) homolog, subfamily B, member 6
IHCImmunohistochemistry of paraffin-embedded human colon cancer using A002452(DNAJB6 antibody) at dilution of 1:100
Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A002452( DNAJB6 Antibody) at dilution of 1:600
Recommended dilutionWB : 1:200-1:2000
Product Description specificalPlays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.