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Alternative name
HSJ2, MRJ, MSJ1 antibody
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Catalog
A002452
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,IF,WB,IP
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PurificationImmunogen affinity purified
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ImmunogenDnaJ (Hsp40) homolog, subfamily B, member 6
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A002452(DNAJB6 antibody) at dilution of 1:100
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A002452( DNAJB6 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalPlays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
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Gene nameDNAJB6
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Uniprot IDO75190
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Observed M.W.27kd
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