anti-AIRE antibody

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  • Alternative name

    AIRE, AIRE1, APECED, APECED protein, APS1, APSI, autoimmune regulator, PGA1 antibody

  • Catalog
    A000241
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman, Mouse
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • Immunogenautoimmune regulator
  • IHCImmunohistochemistry of paraffin-embedded human stomach slide using A000241( AIRE Antibody) at dilution of 1:50
  • Western BlotL02 cells were subjected to SDS PAGE followed by western blot with A000241( AIRE Antibody) at dilution of 1:1000
  • Recommended dilutionWB :1:500-1:5000;IHC:1:20-200
  • Product Description specificalTranscriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
  • Gene nameAIRE
  • locationCytoplasm,Nucleus
  • Uniprot IDO43918
  • Calculated M.W.60kDa
  • Observed M.W.65-70 kDa


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