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Alternative name
Dickkopf 1, Dickkopf related protein 1, DKK 1, DKK1, hDkk 1, SK antibody
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Catalog
A002401
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF,IHC
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PurificationImmunogen affinity purified
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Immunogendickkopf homolog 1 (Xenopus laevis)
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IHCImmunohistochemistry of paraffin-embedded human gliomas tissue slide using A002401( DKK1 Antibody) at dilution of 1:200
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Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A002401(DKK1 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
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Gene nameDKK1
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Uniprot IDO94907
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Observed M.W.30-35 kDa
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