anti-AIM2 antibody

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  • Alternative name

    Absent in melanoma 2, AIM2, PYHIN4 antibody

  • Catalog
    A000238
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • Immunogenabsent in melanoma 2
  • IHCImmunohistochemistry of paraffin-embedded human testis using A000238(AIM2 antibody) at dilution of 1:100
  • Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A000238(AIM2 antibody) at dilution of 1:1000
  • Recommended dilutionWB :1:500-1:5000;IHC:1:20-200
  • Product Description specificalInvolved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
  • Gene nameAIM2
  • locationCytoplasm,Nucleus
  • Uniprot IDO14862
  • Calculated M.W.40kDa
  • Observed M.W.40-45 kDa


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