StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogendifferentially expressed in FDCP 6 homolog ( Mouse )
IHCImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using A002325( DEF6 Antibody) at dilution of 1:50
Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A002325( DEF6 Antibody) at dilution of 1:600
Recommended dilutionWB : 1:200-1:2000
Product Description specificalPhosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).