StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
PurificationImmunogen affinity purified
ImmunogenCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A002051(CTDSP2 antibody) at dilution of 1:50
Western Blothuman kidney tissue were subjected to SDS PAGE followed by western blot with A002051(CTDSP2 antibody) at dilution of 1:400
Recommended dilutionWB : 1:200-1:1000
Product Description specificalPreferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.