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Alternative name
AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, AFF4, MCEF, Protein AF 5q31 antibody
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Catalog
A000196
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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ImmunogenAF4/FMR2 family, member 4
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A000196( AFF4 Antibody) at dilution of 1:600
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Recommended dilutionWB :1:200-1:2000
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Product Description specificalKey component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
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Gene nameAFF4
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locationNucleus
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Uniprot IDQ9UHB7
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Calculated M.W.127kDa,observed 150kDa
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Observed M.W.150 kDa
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