StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
PurificationImmunogen affinity purified
IHCImmunohistochemistry of paraffin-embedded human spleen using A001467(CD33 antibody) at dilution of 1:100
Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A001467(CD33 antibody) at dilution of 1:600
Recommended dilutionWB : 1:200-1:2000
Product Description specificalPutative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).