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Alternative name
ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme antibody
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Catalog
A000139
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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ImmunogenADAM metallopeptidase domain 17
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using A000139( ADAM17-Specific Antibody) at dilution of 1:200
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Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A000139(ADAM17-Specific antibody) at dilution of 1:500
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Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200
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Product Description specificalThe ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
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Gene nameADAM17
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locationMembrane
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Uniprot IDP78536
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Calculated M.W.93kDa,observed 29kDa
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Observed M.W.29 kDa
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