anti-ADAM17-Specific antibody

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  • Alternative name

    ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB
  • PurificationImmunogen affinity purified
  • ImmunogenADAM metallopeptidase domain 17
  • IHCImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using A000139( ADAM17-Specific Antibody) at dilution of 1:200
  • Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A000139(ADAM17-Specific antibody) at dilution of 1:500
  • Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200
  • Product Description specificalThe ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
  • Gene nameADAM17
  • locationMembrane
  • Uniprot IDP78536
  • Calculated M.W.93kDa,observed 29kDa
  • Observed M.W.29 kDa

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