anti-CBLB antibody

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  • Alternative name

    RNF56 antibody

  • Catalog
    A001318
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF
  • PurificationImmunogen affinity purified
  • ImmunogenCas-Br-M (murine) ecotropic retroviral transforming sequence b
  • IHCImmunohistochemistry of paraffin-embedded human lung cancer using A001318(CBLB antibody) at dilution of 1:100
  • Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A001318(CBLB antibody) at dilution of 1:500
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalE3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
  • Gene nameCBLB
  • Uniprot IDQ13191
  • Observed M.W.109 kDa


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