Human NRP1 ELISA Kit

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  • Alternative name

    Human vascular endothelial cell growth factor 165 receptor ELISA Kit;Human NRP ELISA Kit;Human VEGF165R ELISA Kit;Human BDCA4 ELISA Kit;Human CD304 ELISA Kit;Human NP1 ELISA Kit;Human neuropilin 1 ELISA Kit;Human neuropilin-1 ELISA Kit;Human transmembrane receptor ELISA Kit;

  • Catalog
    E007423
  • species
    Human
  • GeneNRP1
  • Other Species Mouse Nrp1 ELISA KitChicken NRP1 ELISA KitRat Nrp1 ELISA Kit
  • SpecificityThe Human CD304 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human CD304 proteins within the range of 780 pg/ml - 50000 pg/ml.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity20 pg/ml.
  • Intended UseHuman NRP1 ELISA Kit allows for the in vitro quantitative determination of NRP1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical
    Principle of the Assay||The Human CD304 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human CD304 in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human CD304 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD304 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human CD304 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD304 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: NRP1 (Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.
  • Human Neuropilin-1 Protein information
  • Uniprot ID NRP1_HUMAN
  • Uniprot AC Q96IH5;
  • UniGene Hs.131704; Hs.653996;
  • GeneID 8829
  • KEGG hsa:8829;
  • Human Neuropilin-1 Protein SEQUENCE
  • SEQUENCE 923 AA; 103134 MW; 1EAC2FA6C8FD6A0B CRC64;

    MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP

    SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR

    GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN

    YTTPSGVIKS PGFPEKYPNS LECTYIVFVP KMSEIILEFE SFDLEPDSNP

    PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD

    SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN

    WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK

    KKYYVKTYKI DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI

    TRFVRIKPAT WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITSS

    NQGDRNWMPE NIRLVTSRSG WALPPAPHSY INEWLQIDLG EEKIVRGIII

    QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE

    LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV

    DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC

    EFGWGSHKTF CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN

    QKGKVARLVS PVVYSQNSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ

    LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI

    NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD KNISRKPGNV

    LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN

    FELVDGVKLK KDKLNTQSTY SEA

  • UCSC uc001iwx.5; human. [O14786-1];


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