Human SLAMF1 ELISA Kit

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  • Alternative name

    Human CDw150 ELISA Kit;Human IPO-3 ELISA Kit;Human SLAM family member 1 ELISA Kit;Human SLAM ELISA Kit;Human CD150 ELISA Kit;Human signaling lymphocytic activation molecule family member 1 ELISA Kit;Human signaling lymphocytic activation molecule ELISA Kit;

  • Catalog
    E007305
  • species
    Human
  • GeneSLAMF1
  • Other Species Mouse Slamf1 ELISA KitCanine SLAMF1 ELISA Kit
  • SpecificityThe Human CD150 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human CD150 proteins within the range of 156 pg/ml - 10000 pg/ml.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity10 pg/ml.
  • Intended UseHuman SLAMF1 ELISA Kit allows for the in vitro quantitative determination of SLAMF1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical
    Principle of the Assay||The Human CD150 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human CD150 in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human CD150 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD150 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human CD150 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD150 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene. It belongs to the immunoglobulin gene superfamily. This gene is mapped to 1q23.3. It has found that SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes and a proportion of B cells, and is rapidly induced on naive T cells after activation. In MV-resistant cell lines, infection with clinical MV and expression of SLAM, but not CD46, caused cytopathic effects (CPE). The expression of SLAM on activated B and T lymphocytes correlates with the pathology of MV infection in humans and monkeys, in which lymphoid organs are the chief sites of MV replication and the binding of MV to SLAM may impair the signaling functions of SLAM in lymphocyte activation and inhibit Th0/Th1 cytokine production, thereby promoting Th2 cytokine production. It has reported that antibody-mediated ligation of SLAM on thymocytes triggered a protein tyrosine phosphorylation signal in T cells in a SAP-dependent manner. This signal also involved SHIP, the adaptor molecules DOK2, DOK1, and SHC and RASGAP.
  • Human Signaling lymphocytic activation molecule Protein information
  • Uniprot ID SLAF1_HUMAN
  • Uniprot AC Q13291; Q5W172; Q9HBE8; W0HKK7;
  • UniGene Hs.523660;
  • GeneID 6504
  • KEGG hsa:6504;
  • Human Signaling lymphocytic activation molecule Protein SEQUENCE
  • SEQUENCE 335 AA; 37231 MW; BFB0F27EA31D8C04 CRC64;

    MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE

    RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL

    ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN

    KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP

    QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM

    ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ

    DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

  • UCSC uc031vca.2; human.;


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