Human ACVRL1 ELISA Kit

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  • Alternative name

    Human SKR3 ELISA Kit;Human Activin receptor-like kinase 1 ELISA Kit;Human ALK-1 ELISA Kit;Human TGF-B superfamily receptor type I ELISA Kit;Human TSR-I ELISA Kit;Human ACVRLK1 ELISA Kit;Human ALK1 ELISA Kit;Human HHT ELISA Kit;Human HHT2 ELISA Kit;Human ORW2 ELISA Kit;Human activin A receptor like type 1 ELISA Kit;Human serine/threonine-protein kinase receptor R3 ELISA Kit;Human activin A receptor type II-like 1 ELISA Kit;Human activin A receptor type IL ELISA Kit;Human activin A receptor, type II-like kinase 1 ELISA Kit;

  • Catalog
    E000560
  • species
    Human
  • GeneACVRL1
  • Standard CurveHuman ACVRL1 ELISA Kit
  • Other Species Mouse Acvrl1 ELISA KitRat Acvrl1 ELISA Kit
  • SpecificityNatural and recombinant Human ALK-1/ACVRL1
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity Intra-assay Precision Intra-Assay Precision (Precision within an assay) Three samples of kn
  • Intended UseHuman ACVRL1 ELISA Kit allows for the in vitro quantitative determination of ACVRL1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical
    Principle of the Assay: Human ALK-1/ACVRL1 ELISA Kit was based on standard sandwich enzyme-linked immunesorbent assay technology. A monoclonal antibody from mouse specific for ALK-1/ACVRL1 has been precoated onto 96-well plates. Standards(Expression system for standard: NSO; Immunogen sequence: D22-Q118) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for ALK-1/ACVRL1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human ALK-1/ACVRL1 amount of sample captured in plate. Background/Introduction: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cellsurface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
  • Human Serine/threonine-protein kinase receptor R3 Protein information
  • Uniprot ID ACVL1_HUMAN
  • Uniprot AC P37023; A6NGA8;
  • UniGene Hs.591026;
  • GeneID 94
  • KEGG hsa:94;
  • Human Serine/threonine-protein kinase receptor R3 Protein SEQUENCE
  • SEQUENCE 503 AA; 56124 MW; 074522AA802325DD CRC64;

    MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW

    CTVVLVREEG RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS

    LVLEATQPPS EQPGTDGQLA LILGPVLALL ALVALGVLGL WHVRRRQEKQ

    RGLHSELGES SLILKASEQG DSMLGDLLDS DCTTGSGSGL PFLVQRTVAR

    QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF RETEIYNTVL

    LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL

    RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG

    LAVMHSQGSD YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA

    FGLVLWEIAR RTIVNGIVED YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT

    IPNRLAADPV LSGLAQMMRE CWYPNPSARL TALRIKKTLQ KISNSPEKPK

    VIQ

  • UCSC uc001rzj.4; human.;


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