Human ACVRL1 ELISA Kit

Alternative name
Human SKR3 ELISA Kit;Human Activin receptor-like kinase 1 ELISA Kit;Human ALK-1 ELISA Kit;Human TGF-B superfamily receptor type I ELISA Kit;Human TSR-I ELISA Kit;Human ACVRLK1 ELISA Kit;Human ALK1 ELISA Kit;Human HHT ELISA Kit;Human HHT2 ELISA Kit;Human ORW2 ELISA Kit;Human activin A receptor like type 1 ELISA Kit;Human serine/threonine-protein kinase receptor R3 ELISA Kit;Human activin A receptor type II-like 1 ELISA Kit;Human activin A receptor type IL ELISA Kit;Human activin A receptor, type II-like kinase 1 ELISA Kit;
Catalog
E000560
species
Human
GeneACVRL1
Standard Curve
Other Species Mouse Acvrl1 ELISA Kit Rat Acvrl1 ELISA Kit
SpecificityNatural and recombinant Human ALK-1/ACVRL1
SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
Sensitivity Intra-assay Precision Intra-Assay Precision (Precision within an assay) Three samples of kn
Intended UseHuman ACVRL1 ELISA Kit allows for the in vitro quantitative determination of ACVRL1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
StorageStore the whole ELISA kit at 4℃
Product Description
specificalPrinciple of the Assay: Human ALK-1/ACVRL1 ELISA Kit was based on standard sandwich enzyme-linked immunesorbent assay technology. A monoclonal antibody from mouse specific for ALK-1/ACVRL1 has been precoated onto 96-well plates. Standards(Expression system for standard: NSO; Immunogen sequence: D22-Q118) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for ALK-1/ACVRL1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human ALK-1/ACVRL1 amount of sample captured in plate. Background/Introduction: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cellsurface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Human Serine/threonine-protein kinase receptor R3 Protein information
Uniprot ID ACVL1_HUMAN
Uniprot AC P37023; A6NGA8;
UniGene Hs.591026;
GeneID 94
KEGG hsa:94;
Human Serine/threonine-protein kinase receptor R3 Protein SEQUENCE
SEQUENCE 503 AA; 56124 MW; 074522AA802325DD CRC64;
MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW
CTVVLVREEG RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS
LVLEATQPPS EQPGTDGQLA LILGPVLALL ALVALGVLGL WHVRRRQEKQ
RGLHSELGES SLILKASEQG DSMLGDLLDS DCTTGSGSGL PFLVQRTVAR
QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF RETEIYNTVL
LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL
RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG
LAVMHSQGSD YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA
FGLVLWEIAR RTIVNGIVED YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT
IPNRLAADPV LSGLAQMMRE CWYPNPSARL TALRIKKTLQ KISNSPEKPK
VIQ
UCSC uc001rzj.4; human.;

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Human ACVRL1 ELISA Kit