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Human BGN ELISA Kit

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  • Alternative name

    Human Bone/cartilage proteoglycan I ELISA Kit;Human PG-S1 ELISA Kit;Human SLRR1A ELISA Kit;Human DSPG1 ELISA Kit;Human MRLS ELISA Kit;Human PGI ELISA Kit;Human SEMDX ELISA Kit;Human biglycan ELISA Kit;Human bone/cartilage proteoglycan-I ELISA Kit;Human dermatan sulphate proteoglycan I ELISA Kit;Human small leucine-rich protein 1A ELISA Kit;
  • Catalog
    E004961
  • species
    Human
  • GeneBGN
  • Other Species Mouse Bgn ELISA KitBovine BGN ELISA KitCanine BGN ELISA KitHorse BGN ELISA KitPorcine BGN ELISA KitRabbit BGN ELISA KitRat Bgn ELISA KitSheep BGN ELISA KitHuman Big ET-1 ELISA Kit
  • SpecificityThe Human Biglycan ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Biglycan proteins within the range of 156 pg/ml - 10000 pg/ml.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity10 pg/ml.
  • Intended UseHuman BGN ELISA Kit allows for the in vitro quantitative determination of BGN , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the Assay||The Human Biglycan ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human Biglycan in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human Biglycan coated on a 96-well plate. Standards and samples are pipetted into the wells and Biglycan present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human Biglycan antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of Biglycan bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: Biglycan (BGN) is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. It is an important structural component of articular cartilage and participates in the assembly of the chondrocyte extracellular matrix through formation of protein interactions with type VI collagen and large proteoglycan aggregates. In humans, Biglycan is encoded by the BGN gene. It is mapped to Xq28. Biglycan is believed to play a role in the mineralisation of bone, and its core protein binds to the growth factors BMP-4 and influences its bioactivity. It has been reported that the presence of biglycan is necessary for BMP-4 to exert its effects on osteoblasts. There is also evidence that biglycan can bind to TGF-beta 1. In addition, Biglycan plays an important role in cell signaling.
  • Human Biglycan Protein information
  • Uniprot ID PGS1_HUMAN
  • Uniprot AC P21810; D3DWU3; P13247;
  • UniGene Hs.821;
  • GeneID 633
  • KEGG hsa:633;
  • Human Biglycan Protein SEQUENCE

  • SEQUENCE 368 AA; 41654 MW; BF16F304C5CD3B3E CRC64;

    MWPLWRLVSL LALSQALPFE QRGFWDFTLD DGPFMMNDEE ASGADTSGVL

    DPDSVTPTYS AMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN

    DISELRKDDF KGLQHLYALV LVNNKISKIH EKAFSPLRKL QKLYISKNHL

    VEIPPNLPSS LVELRIHDNR IRKVPKGVFS GLRNMNCIEM GGNPLENSGF

    EPGAFDGLKL NYLRISEAKL TGIPKDLPET LNELHLDHNK IQAIELEDLL

    RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLA RVPSGLPDLK

    LLQVVYLHSN NITKVGVNDF CPMGFGVKRA YYNGISLFNN PVPYWEVQPA

    TFRCVTDRLA IQFGNYKK

  • UCSC uc004fhr.3; human.;


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