Mouse Col17a1 ELISA Kit

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  • Alternative name

    Collagen alpha-1(XVIII) chain ELISA KIT; Col18a1 ELISA KIT;

  • Catalog
    E049080
  • species
    Mouse. There is no detectable cross-reactivity with other relevant proteins.
  • GeneCOL18A1
  • Other Species Human COL18A1 ELISA KitMouse Col18a1 ELISA KitMouse COL18A1/ES ELISA Kit
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity Immunogen NSO, H1591-K1774
  • Intended UseMouse Col17a1 ELISA Kit allows for the in vitro quantitative determination of COL18A1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageFor 5-7days:Store the whole kit at 4℃
    For a Long time :Store the Substrate at 4℃, other reagent should store at -20℃.
  • Product Description
    specifical
    Description: Sandwich ELISA kit of Quantitative Detection for Mouse Endostatin Background: Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.


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