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Mouse Il7r ELISA Kit

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  • Alternative name

    Mouse IL-7 receptor subunit alpha ELISA Kit;Mouse IL-7R subunit alpha ELISA Kit;Mouse IL-7R-alpha ELISA Kit;Mouse IL-7RA ELISA Kit;Mouse CD127 ELISA Kit;Mouse IL-7Ralpha ELISA Kit;Mouse interleukin 7 receptor ELISA Kit;Mouse interleukin-7 receptor subunit alpha ELISA Kit;Mouse IL-7 receptor alpha chain ELISA Kit;Mouse interleukin 7 receptor alpha chain ELISA Kit;
  • Catalog
    E047586
  • species
    Mouse
  • GeneIl7r
  • Other Species Human IL7R ELISA KitHorse IL7R ELISA Kit
  • SpecificityThe Mouse CD127 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Mouse CD127 proteins within the range of 312 pg/ml - 20000 pg/ml.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity10 pg/ml.
  • Intended UseMouse Il7r ELISA Kit allows for the in vitro quantitative determination of Il7r , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the Assay||The Mouse CD127 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Mouse CD127 in Cell Culture Supernatants, Serum. This assay employs an antibody specific for Mouse CD127 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD127 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Mouse CD127 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD127 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: The interleukin-7 receptor (IL7R) is a protein found on the surface of cells. It is mapped to 5p13.2. The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. IL7R has been shown to play a critical role in the development of immune cells called lymphocytes-specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. What's more, IL7R antagonism is efficacious in treatment of EAE through its effects on Th17 cells and is a potential treatment for MS.
  • Mouse Interleukin-7 receptor subunit alpha Protein information
  • Uniprot ID IL7RA_MOUSE
  • Uniprot AC P16872; Q9R0C1;
  • UniGene Mm.389;
  • GeneID 16197
  • KEGG mmu:16197;
  • Mouse Interleukin-7 receptor subunit alpha Protein SEQUENCE

  • SEQUENCE 459 AA; 51605 MW; 52ADF78C8C01D2EE CRC64;

    MMALGRAFAI VFCLIQAVSG ESGNAQDGDL EDADADDHSF WCHSQLEVDG

    SQHLLTCAFN DSDINTANLE FQICGALLRV KCLTLNKLQD IYFIKTSEFL

    LIGSSNICVK LGQKNLTCKN MAINTIVKAE APSDLKVVYR KEANDFLVTF

    NAPHLKKKYL KKVKHDVAYR PARGESNWTH VSLFHTRTTI PQRKLRPKAM

    YEIKVRSIPH NDYFKGFWSE WSPSSTFETP EPKNQGGWDP VLPSVTILSL

    FSVFLLVILA HVLWKKRIKP VVWPSLPDHK KTLEQLCKKP KTSLNVSFNP

    ESFLDCQIHE VKGVEARDEV ESFLPNDLPA QPEELETQGH RAAVHSANRS

    PETSVSPPET VRRESPLRCL ARNLSTCNAP PLLSSRSPDY RDGDRNRPPV

    YQDLLPNSGN TNVPVPVPQP LPFQSGILIP VSQRQPISTS SVLNQEEAYV

    TMSSFYQNK

  • UCSC uc007vfo.2; mouse.;


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