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Alternative name
Tryptophan--tRNA ligase 1 ELISA KIT; Tryptophanyl-tRNA synthetase 1trpS1 ELISA KIT;
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Catalog
E039715
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species
Human
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GeneSCO3334
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SpecificityThis kit exhibits no detectable cross-reactivity with HRS, KRS, NRS, SRS, YRS, GRS and AIMP1
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SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
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SensitivityThe minimum detectable dose of WRS was determined by two standard deviations to the mean value of 20 blank samples. The minimum detectable dose of human WRS using a standard curve generated is 0.45 ng/ml.
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Intended UseHuman SCO3334 ELISA Kit allows for the in vitro quantitative determination of SCO3334 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
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StorageFor 5-7days:Store the whole kit at 4℃
For a Long time :Store the Substrate at 4℃, other reagent should store at -20℃.
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Product Categories/FamilyCytokines & Cell Signalling; Research Assays; Assay Categories
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Product Description
specificalBackground: WRS was the first aminoacyl-tRNA synthetase(ARS) for which cytokine activities have been propozed among ARSs. WRS is regulated not only at the level of posttranslational proteolysis, but also at the levels of transcription initiation and alternative splicing. It was shown that gene expression of WRS is regulated by interferon-?(IFN-?). At present time, major alternative form (mini-WRS) with reduced NH-terminus blocks EGF-induced angiogenesis by initiating apoptosis of endothelial cells. Interestingly, WRSinduced apoptosis similarly to AIMP1 induced apoptosis concentration dependent and is observed only at concentration of WRS>50 nM.
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