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Human TGFBR3 ELISA Kit

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  • Alternative name

    Human TGF-beta receptor type 3 ELISA Kit;Human TGFR-3 ELISA Kit;Human betaglycan ELISA Kit;Human transforming growth factor beta receptor III ELISA Kit;Human TGF-beta receptor type III ELISA Kit;Human BGCAN ELISA Kit;Human transforming growth factor beta receptor 3 ELISA Kit;Human transforming growth factor beta receptor type 3 ELISA Kit;Human betaglycan proteoglycan ELISA Kit;
  • Catalog
    E037955
  • species
    Human
  • GeneTGFBR3
  • Standard CurveHuman TGFBR3 ELISA Kit
  • Other Species Mouse Tgfbr3 ELISA KitPorcine TGFBR3 ELISA KitRat Tgfbr3 ELISA Kit
  • SpecificityNatural and recombinant human TGFBR3
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity Sample For quantitative detection of human TGFBR3 in cell culture supernates, serum and pla
  • Intended UseHuman TGFBR3 ELISA Kit allows for the in vitro quantitative determination of TGFBR3 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the assay: Human TGFBR3 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for TGFBR3 has been precoated onto 96-well plates. Standards(NSO,G21-D781) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for TGFBR3 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human TGFBR3 amount of sample captured in plate. Background: Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell- surfacechondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. By cDNA array and immunohistochemistry analyses, it is found that TGFBR3 expression is lost in most breast cancers examined in association with loss of heterozygosity of the TGFBR3 locus. TGFBR3 expression decreased during breast cancer progression, and low levels predicted decreased recurrence-free survival in patients. Loss of TGFBR3 through allelic imbalance is a frequent genetic event during breast cancer development that increases metastatic potential. Also, TGFBR3 can localize transformation in the heart and play an essential, nonredundant role in TGF-beta signaling.
  • Human Transforming growth factor beta receptor type 3 Protein information
  • Uniprot ID TGBR3_HUMAN
  • Uniprot AC Q03167; A0AUW8; A8K5N0; B9EG88; Q5T2T4; Q5U731; Q9UGI2;
  • UniGene Hs.482390; Hs.735919;
  • GeneID 7049
  • KEGG hsa:7049;
  • Human Transforming growth factor beta receptor type 3 Protein SEQUENCE

  • SEQUENCE 851 AA; 93499 MW; AEC56C4477C003B2 CRC64;

    MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS

    GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV

    VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE

    RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG

    KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV

    DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI

    GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR

    FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG

    LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI

    ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES

    PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF

    PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT

    DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM

    SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL

    LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK

    PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL

    LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST

    A

  • UCSC uc001doh.4; human. [Q03167-1];


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