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Human PLAUR ELISA Kit

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  • Alternative name

    Human U-PAR ELISA Kit;Human UPAR ELISA Kit;Human monocyte activation antigen Mo3 ELISA Kit;Human MO3 ELISA Kit;Human CD87 ELISA Kit;Human URKR ELISA Kit;Human plasminogen activator, urokinase receptor ELISA Kit;Human urokinase plasminogen activator surface receptor ELISA Kit;Human u-plasminogen activator receptor form 2 ELISA Kit;Human urokinase-type plasminogen activator (uPA) receptor ELISA Kit;
  • Catalog
    E029618
  • species
    Human
  • GenePLAUR
  • Other Species Human PLAUR/uPAR ELISA KitMouse Plaur ELISA KitMouse PLAUR/uPAR ELISA KitBovine PLAUR ELISA KitMonkey PLAUR ELISA KitRat Plaur ELISA Kit
  • SpecificityThis assay has high sensitivity and excellent specificity for detection of Human PLAUR. No significant cross-reactivity or interference between Human PLAUR and analogues was observed.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity0.039 ng/ml
  • Intended UseHuman PLAUR ELISA Kit allows for the in vitro quantitative determination of PLAUR , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Introduction: uPAR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. In order to be able toreorganize tissue it is important, that the old tissue can be degraded. An important mechanism in this degradation is the proteolysis cascade initiated by the plasminogen activation system. uPAR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus uPAR seems to be an important player in the regulation of this process. However the components of the plasminogen activation system have been found to be highly expressed in many malignant tumors, indicating that tumors are able to hijack the system, and use it in metastasis. Thus inhibitors of the various components of the plasminogen activation system has been sought as possible anticancer drugs. uPAR has been involved in various other non-proteolytical processes related to cancer, such as cell migration, cell cycle regulation and cell adhesion. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to uPAR. Standards or samples are then added to the appropriate microtiter plate wells with a biotin conjugated polyclonal antibody preparation specific for uPAR. and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3'5, 5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain uPAR., biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of uPAR. in the samples is then determined by comparing the O.D. of the samples to the standard curve.
  • Human Urokinase plasminogen activator surface receptor Protein information
  • Uniprot ID UPAR_HUMAN
  • Uniprot AC Q9UD69; Q9UEA6; Q9UM92; Q9UMV0;
  • UniGene Hs.466871;
  • GeneID 5329
  • KEGG hsa:5329;
  • Human Urokinase plasminogen activator surface receptor Protein SEQUENCE

  • SEQUENCE 335 AA; 36978 MW; AB1963EA3DC77171 CRC64;

    MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI

    VRLWEEGEEL ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ

    GNSGRAVTYS RSRYLECISC GSSDMSCERG RHQSLQCRSP EEQCLDVVTH

    WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG FHNNDTFHFL KCCNTTKCNE

    GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP MNQCLVATGT

    HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV

    QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT

  • UCSC uc002oxd.3; human. [Q03405-1];


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