Human PCSK9 ELISA Kit

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  • Alternative name

    Human Neural apoptosis-regulated convertase 1 ELISA Kit;Human NARC-1 ELISA Kit;Human Proprotein convertase 9 ELISA Kit;Human PC9 ELISA Kit;Human subtilisin/kexin-like protease PC9 ELISA Kit;Human NARC1 ELISA Kit;Human FH3 ELISA Kit;Human HCHOLA3 ELISA Kit;Human LDLCQ1 ELISA Kit;Human proprotein convertase subtilisin/kexin type 9 ELISA Kit;Human convertase subtilisin/kexin type 9 preproprotein ELISA Kit;Human neural apoptosis regulated convertase 1 ELISA Kit;

  • Catalog
    E028403
  • species
    Human
  • GenePCSK9
  • Other Species Mouse Pcsk9 ELISA KitRat Pcsk9 ELISA Kit
  • SpecificityNatural and recombinant human PCSK9
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity< 10pg/ml
  • Intended UseHuman PCSK9 ELISA Kit allows for the in vitro quantitative determination of PCSK9 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical
    Principle of the assay: human PCSK9 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for PCSK9 has been precoated onto 96-well plates. Standards(NSO, S153-Q692) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for PCSK9 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human PCSK9 amount of sample captured in plate. Background: Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, the PCSK9 gene was mapped to chromosome 1p32. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins (LDL), which could lead to hypercholesterolemia. PCSK9 may also have a role in the differentiation of cortical neurons.
  • Human Proprotein convertase subtilisin/kexin type 9 Protein information
  • Uniprot ID PCSK9_HUMAN
  • Uniprot AC Q8NBP7; A8T640; C0JYY9; Q5PSM5; Q5SZQ2;
  • UniGene Hs.18844;
  • GeneID 255738
  • KEGG hsa:255738;
  • Human Proprotein convertase subtilisin/kexin type 9 Protein SEQUENCE
  • SEQUENCE 692 AA; 74286 MW; 9BCB9418B90AEE23 CRC64;

    MGTVSSRRSW WPLPLLLLLL LLLGPAGARA QEDEDGDYEE LVLALRSEED

    GLAEAPEHGT TATFHRCAKD PWRLPGTYVV VLKEETHLSQ SERTARRLQA

    QAARRGYLTK ILHVFHGLLP GFLVKMSGDL LELALKLPHV DYIEEDSSVF

    AQSIPWNLER ITPPRYRADE YQPPDGGSLV EVYLLDTSIQ SDHREIEGRV

    MVTDFENVPE EDGTRFHRQA SKCDSHGTHL AGVVSGRDAG VAKGASMRSL

    RVLNCQGKGT VSGTLIGLEF IRKSQLVQPV GPLVVLLPLA GGYSRVLNAA

    CQRLARAGVV LVTAAGNFRD DACLYSPASA PEVITVGATN AQDQPVTLGT

    LGTNFGRCVD LFAPGEDIIG ASSDCSTCFV SQSGTSQAAA HVAGIAAMML

    SAEPELTLAE LRQRLIHFSA KDVINEAWFP EDQRVLTPNL VAALPPSTHG

    AGWQLFCRTV WSAHSGPTRM ATAVARCAPD EELLSCSSFS RSGKRRGERM

    EAQGGKLVCR AHNAFGGEGV YAIARCCLLP QANCSVHTAP PAEASMGTRV

    HCHQQGHVLT GCSSHWEVED LGTHKPPVLR PRGQPNQCVG HREASIHASC

    CHAPGLECKV KEHGIPAPQE QVTVACEEGW TLTGCSALPG TSHVLGAYAV

    DNTCVVRSRD VSTTGSTSEG AVTAVAICCR SRHLAQASQE LQ

  • UCSC uc001cyf.3; human. [Q8NBP7-1];


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